Genentech Planning to Lay Off 223 Employees

                                                                                          Issue # 2751 | August 17th, 2018      
















































































































































































News Alert



Genentech Planning to Lay Off 223 Employees

Genentech will be laying off 223 employees located at its South San Francisco, California, headquarters beginning at the end of this month, the company disclosed in a recent state filing. The effective dates for the layoffs will run from August 31st into November, 2018. The layoffs were documented in a Worker Adjustment and Retraining Notification (WARN) post by the State of California's Employment Development Department. These new layoffs will be across various departments, but all will be in South San FranciscoLearn More




Pfizer Paying $120M Upfront for Vaccine Collaboration

Pfizer is teaming up with Germany's BioNTech to create a new influenza vaccine based on messenger RNA technology in  a collaboration worth up to $425 million . The companies will jointly contribute to R&D efforts until the vaccines make it through first-in-human testing, at which point Pfizer will take full control. Per the terms of the deal, BioNTech will get $120 million in upfront, equity and near-term research payments and could receive an additional $305 million in various milestone payments. The biotech is also eligible for up to double-digit tiered royalty payments on worldwide sales of any vaccine that reaches the market.  Learn More




Chinese Government Removes Local and Regulatory Leaders as Vaccine Scandal Reaches 900,000

The Chinese government this week removed from office local leaders representing the city and region home to the headquarters of Changchun Changsheng Life Sciences. The biopharma at the center of the vaccine scandal effecting 900,000+ children in China and counting. A deputy director of China's drug regulator was also dismissed, while another has been announced as the subject of an investigation. This comes after the company's CEO and 14 other officials were reported to have been detained. Alert readers will recall that back in 2007 China executed the man then in charge of its drug regulator  following 10 deaths attributed to an antibiotic whose approval had been bought with bribes.  Learn More

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TED Alert

Meet Spot, the Robot Dog that can Run, Hop and Open Doors


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That science fiction future where robots can do what people and animals do may be closer than you think. Marc Raibert, founder of Boston Dynamics, is developing advanced robots that can gallop like a cheetah, negotiate 10 inches of snow, walk upright on two legs and even open doors and deliver packages. Join Raibert for a live demo of SpotMini, a nimble robot that maps the space around it, handles objects, climbs stairs -- and could soon be helping you out around the house. Learn More

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Are new medical treatments made available before we fully understand their health effects?
     


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Bioprocess Alert

Sequencing Amino Acids in Proteins


This video, which has 12,000+ views, provides insight into the challenges associated with sequencing amino acids in proteins. Learn More

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Webinar: Raman as a PAT Tool for Continuous Manufacturing of Solid Dose Pharmaceutical Product
 
August 29th, 2018

The pharmaceutical industry is increasing the rate of adoption of advanced manufacturing techniques such as continuous manufacturing. Manufacturing approaches such continuous rely on in-process measurements to a much larger extent than previous ones. NIR spectroscopy has historically been the predominant spectroscopic measurement for these in-process requirements. More recent advances in Raman technology along with other benefits such as increased chemical specificity and reduced interference from physical changes make it an appealing option which is seeing an increase in adoption in-process. Here we will present work demonstrating the utilization of the Kaiser Raman system within a continuous pharmaceutical tableting line along with comparisons to NIR.


Resource Alert



A Multi-Column Plate Adapter Provides an Economical and Versatile High-Throughput Protein Purification System

Protein purification is essential in the study of protein structure and function, and the development of novel therapeutics. Many studies require purifying multiple proteins at once, increasing the demand for improved purification methods. We hypothesized that multiple chromatography columns could be interfaced with a multi-well collection plate for rapid and convenient protein purification without the need of expensive instrumentation. As such, we developed a multi-column plate adapter (MCPA), which provides an economical yet versatile and time efficient, high-throughput protein purification system.  Learn More

 
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Regulatory Alert



CDER Director Woodcock Shares Her Views on Real World Evidence in JAMA

Leaders of CDER at the U.S. FDA, including Director Janet Woodcock, have shared their view on the role of real world evidence in JAMA this week. This is in response to a requirement of the 21st Century Cures Act that the FDA have a framework to evaluate the use of RWE by the end of this year. The idea is to leverage real-world evidence to support the approval of new indications for approved drugs or to satisfy post-approval study requirements. According to the FDA, RWE is defined as "the clinical evidence regarding the usage and potential benefits or risks of a medical product derived from analysis of RWD [real world data]."  Learn More

Discovery Alert



Cells Agree: What Doesn't Kill You Makes You Stronger